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sparsentan will lessen the extent or result of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and decreases efficacy related to these substrates.modafinil will lessen the extent or outcome of mavacamten by influencing hepatic/intestinal